![]() ![]() 11 Comparing BLAST and the Smith-Waterman ProcessīLAST is one of the most widely used bioinformatics programs, because it addresses a fundamental problem and the heuristic algorithm it uses is much faster than calculating an optimal alignment.Lipman at the NIH and was published in the Journal of Molecular Biology in 1990. ![]() The BLAST program was designed by Stephen Altschul, Warren Gish, Webb Miller, Eugene Myers, and David J. For example, following the discovery of a previously unknown gene in the mouse, a scientist will typically perform a BLAST search of the human genome to see if humans carry a similar gene BLAST will identify sequences in the human genome that resemble the mouse gene based on similarity of sequence. Different types of BLASTs are available according to the query sequences. A BLAST search enables a researcher to compare a query sequence with a library or database of sequences, and identify library sequences that resemble the query sequence above a certain threshold. In bioinformatics, Basic Local Alignment Search Tool, or BLAST, is an algorithm for comparing primary biological sequence information, such as the amino-acid sequences of different proteins or the nucleotides of DNA sequences. ![]() Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ, NCBIĢ.2.27+ / 11 September 2012 6 months ago ( ) ![]()
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